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"A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3)"

This stepwise dosing approach was designed to minimize gastrointestinal symptoms (nausea, vomiting, and diarrhea) and help clinicians distinguish between the levels at which the drug remains tolerable and those that maximize therapeutic benefit

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The dose of the drug was adjusted weekly throughout the study period based on changes in the weight of the mice