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Part of that difference comes down to a hormone most people have never heard of: GLP-1

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retatrutide data are at 48 weeks only Population differences : Participant demographics, baseline BMI, and comorbidity profiles may differ Dose optimization : Retatrutide's Phase 3 may use different doses than Phase 2 A head-to-head randomized trial would be needed to definitively establish relative efficacy

It is especially beneficial for people with diagnosed B12 deficiency, which can cause fatigue, weakness, and difficulty losing weight

10.1111/jfbc.13757 111 ShiL.DengJ.HeJ.ZhuF.JinY.ZhangX.et al (2024)

How effective is Ozempic in treating type 2 diabetes and obesity