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Although there was no statistically significant difference between the control DSS and Si-DSS groups, it was found that the expression of inflammatory cytokines in the colon was also suppressed by the Si-based agent

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The findings suggest that the preprocedural fasting duration suggested by current guidelines may be inadequate in this group of patients at increased risk of aspiration under anesthesia.

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The Mounjaro (tirzepatide) UK SmPC advises using a barrier method of contraception for four weeks after initiation and after each dose escalation, as tirzepatide has been shown to reduce oral contraceptive exposure during these periods