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In contrast, GLP-1 receptor agonists approved by the FDAincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound, which also activates GIP receptors)are modified to resist DPP-4 degradation

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Sources: CLC016638.A This content is not intended to be a substitute for professional medical advice, diagnosis or treatment

Later on, studies found that they can be used to promote weight loss, as well, by reducing hunger and food intake

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Orforglipron is an oral non-peptide GLP-1 agonist that could solve the injection barrier entirely