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As described in the two-step model of NLRP3 preparation and activation, the initiation step manifests in NLRP3 overexpression and the activation step is required for NLRP3 oligomerization and inflammasome assembly to allow processing of pro-IL-1 and pro-IL-18 into their mature, secreted forms [64]

The glycoaldehyde is ultimately metabolized to glyoxylate

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doi: 2 10.12788/j.sder.12018.12056

11.2.3 Polymeric nanoparticles (PNPs)a platform with established precedent, lacking CUL5-Specific evidence Conventional polymeric nanoparticles (PNPs) are composed of a polymer backbone conjugated with therapeutic agents (182)

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