In our experiments, the concentration of CB-839 needed for effective, functional glutaminase inhibition varied from 10 nM to 1 M, and the antiproliferative IC 50 was determined as 0.41 M for the HG-3 cell line and 66.2 M for the MEC-1 cell line
However, implementing such personalized recommendations on a large scale requires a paradigm shift in healthcare systems, moving towards individualized care
How politically viable is that, you might ask
Actinic keratosis occurs most commonly on the face or the top of the hands
Am J Respir Crit Care Med 162 : 23412351 Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J 2005 Standardisation of spirometry
Wasserman K, McIlroy MB