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Additionally, AMDs pathogenesis involves the loss of RPE-derived VEGF signaling and defenestration of usually high permeable choriocapillaries in atrophied RPE areas, which disrupts retinal permeability [440, 441]

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The other 75% is dependent on environmental factors

It stimulates fibroblast and keratinocyte proliferation, aiding re-epithelialization and ECM remodeling

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Pancreatic cancer studies have shown that broad depletion of stromal elements or carcinoma-associated fibroblasts can accelerate disease progression and worsen immunosuppression in some settings [70, 97]