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FcRn is found in both hematopoietic and non-hematopoietic cells, including endothelial and epithelial cells as well as monocytes, macrophages, neutrophils, B cells, and dendritic cells

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The proline substitutions at positions 25, 28 and 29 reduce fibrillation propensity relative to native amylin but do not abolish it, so avoid mechanical shear, avoid leaving concentrated solution standing at room temperature, and inspect for haze, filaments or opalescence before use

Proc Natl Acad Sci U S A 106:39415

For storage, the peptide should be kept frozen while in lyophilized form and refrigerated after reconstitution to help preserve stability and handling consistency

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