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Start your intake What the triple-agonist mechanism is and how it differs from dual agonists Retatrutide activates three receptors at once: GLP-1 (appetite suppression and insulin response), GIP (insulin response and adipose handling, the receptor tirzepatide adds on top of GLP-1), and glucagon (energy expenditure and hepatic fat metabolism)

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Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta-analysis of randomized controlled trials

10.1186/s13023-018-0758-x 160 McCabeS

2020, doi: 10.1038/s41574-020-0399-8