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An eye cream study in 41 women over the same period showed GHK-Cu outperformed both placebo and vitamin K cream in reducing lines and wrinkles while increasing skin density

PMC 8236484

In other words, you get B12 at the same rate you use it

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Progesterone is often sedating, which is helpful for insomnia, but may not be tolerated by everyone

Whittemore K, Vera E, Martnez-Nevado E, Sanpera C, Blasco MA (2019) Telomere shortening rate predicts species life span