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The propeptides are cleaved by endopeptidases after secretion into the extracellular space (extracellular activation) or before they are incorporated into storage vesicles (intracellular activation) [21, 22]

Peptide aggregation has not been assessed in human studies

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FDA.gov (2026) 14

predominantly done in mice have shown that atrial fibrosis associated with type 2 diabetes is one of the main reasons for creating substrates for reentry, which is responsible for recurrence and maintenance of AF

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