3.1.3 DON DON (6-diazo-5-oxo-l-norleucine), a glutamine analog, irreversibly inhibits various glutamine utilization enzymes, such as glutaminase and glutamine synthetase, by forming covalent bonds with nucleophilic residues on the active site of the enzyme (Rajagopalan and DeBerardinis, 2011
AD is highly associated with cellular oxidative stress that contributes to increased protein oxidation, glycol oxidation, lipid peroxidation and A accumulation
Western blot analysis quantified protein expression levels, utilizing total protein extracts as well as nuclear and cytoplasmic fractions
Bian G, Xu Y, Lu P, Xie Y, Xi Z
C57BL/6 mice are relatively more resistant to hepatocarcinogens than C3H and C57BL/6 x C3H F1 mice
Third, a transitional immune status between types 1 and type 2