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10.2337/dc13-2761 [DOI] [PMC free article] [PubMed] [Google Scholar] Nauck M

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The glia-neuron lactate shuttle in the CNS has been found to be crucial for axonal myelination and integrity

Among them, the profile-based CDR strategy supposes that pharmacologic perturbations caused by small molecules are comparable even under varying biological conditions since repurposed small molecules share similar therapeutic mechanisms or modes of action (MOAs) [1]

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