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The most clinically relevant Z variant of AAT protein differs from the normal M by a single amino acid substitution (Glu342Lys)

TB-500 in horse racing Research has shown that TB-500 is commonly used in horse racing as a doping drug [3], and active efforts are currently underway to completely ban its use from this sport [4]: Under Australias strict drug-free racing policy, anyone found guilty of injecting TB-500 into a racehorse would receive a minimum period of disqualification of two years: We have been aware of this substance for a number of years and we are confident we have the strategies and testing capabilities to control it

10.1016/j.molonc.2012.02.004 24 HuY.WangY.HongH.ChenY.ZhouQ.ZhuG.et al (2024)

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Supplementing with actual glutathione (in liposomal form) provides the finished molecule directly to the cells