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8 Challenges and Considerations in Multi-Agonist Therapy Despite their advantages, GLP-1-based therapies face several challenges in adolescent populations: Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, and constipation are common adverse events, especially during dose escalation

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Oxidative stress occurs when the body's ability to resist free radicals and its ability to make them are out of balance