Key Takeaways Vitamin B12 itself does not act like a laxative
We are working on educational material for Healthcare Professionals (watch this space early in 2025) and patients: How Vitamin B12 Works in your Body We lobbied the Royal College of GPs about training and awareness about B12 deficiency and Pernicious Anaemia and they have now agreed to write an EKU module for doctors on this topic
Methylcobalamin A bioactive form of B12
4.8 Caspase-Glo 3/7 assay Caspases 3 and 7 activation were measured using Caspase-Glo 3/7 (Promega)
Enhancing Antioxidant Defenses: By bolstering the cell's natural antioxidant systems, MOTS-c helps to neutralize harmful free radicals, protecting cells from oxidative damage
The change was -2.7 [95% confidence interval (CI): -3.9, -1.5] in the mecobalamin 50 mg group and -4.6 [95% CI: -5.8, -3.4] in the placebo group, with a difference in change of 2.0 (95% CI: 0.4, 3.5