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10.1016/j.bbamem.2006.07.007
It is not established whether enough peptide survives first-pass absorption to produce meaningful systemic plasma concentrations for non-gastrointestinal targets
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A study using 92% pure BPC-157 may show marginal mucosal healing, while the same dose at 98% purity produces statistically significant results, creating apparent contradictions in the literature
Companies like InfiniWell are using lipid encapsulation to protect peptides from degradation and dramatically improve absorption through mucosal tissue
Trials typically employed a structured dose-escalation pattern to manage tolerability
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