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Impact of insulin and insulin resistance on brain dopamine signalling and reward processingan underexplored mechanism in the pathophysiology of depression

One key limitation is the variability in individual responses to melatonin treatment

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Notably, oxidative stress-a well-established inducer of ferroptosis-has also been recognized as a critical driver of AD pathology [118]

Finally, CARM1 catalyzes histone H3R26 methylation to prevent the recruitment of the super elongation complex and suppress the long terminal repeat (LTR)-mediated transcription of viral genes [186]