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Recent investigations also identified various deletion mutations and rearrangements of mtDNA with altered copy numbers in nigral neurons of sporadic PD patients and experimental models of PD, but their significance in PD pathogenesis could not be established as yet (Martn-Jimnez et al., 2020)

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Back Barany, G, Barany, MJ (27 Sept 2024) 'Foundational contributions of Svetlana Mojsov to the GLP-1 field', Explorations of Drug Science , 2, 688700

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The mechanism involves gene regulation in chondrocytes (cartilage cells) - Cartalax binds to specific DNA sequences in cartilage tissue, upregulating genes for cartilage matrix proteins (collagen type II, proteoglycans, aggrecan), downregulating inflammatory and degradative enzymes (matrix metalloproteinases), and optimizing the balance between cartilage formation and breakdown