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13 A 97.5% normal threshold is associated with a much lower false-positive rate and is recommended by the European Federation of Neurological Societies (now the European Academy of Neurology)

It generally needs to be administered around 45 minutes before sexual activity

The medication is the lever

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Later that year, however, a new observational study published in JAMA Network Open reignited the debate around the safety of the class, prompting the FDA to take another look

These medications should be discontinued before a planned pregnancy, as their effects on fetal development are still being studied