The ESSENCE trial will provide valuable data on the maintenance of histological benefits over 240 weeks of continuous treatment, but long-term extension studies and off-treatment follow-up protocols are needed to characterize rebound kinetics
The interplay of multiple hormones and signaling pathways involved in PWS suggests a complex network that is not yet fully understood
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Diabetologia 54 , 27452754 (2011)
Sanitation standards that are typically met in medical offices cannot be replicated at home, and emergency response equipment is not available in the event of an adverse reaction
References Saha, S., Chant, D., Welham, J