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Understanding whether you carry variants associated with lower baseline GLP-1 signaling or reduced appetite regulation can support a more informed conversation with your provider about whether GLP-1 therapy (compounded or otherwise) may be clinically appropriate for you, independent of dietary choices

Important safety information: Tirzepatide has a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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172,173 Conversely, DGAT1 ablation may result in elevated DAG levels and lipid-induced IR

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