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But potency decreases incrementally each day after reconstitution, and by week 4 or 5, the degradation may become meaningful enough to affect your results

Published Phase 3 efficacy-estimand data shows retatrutide at 12 mg producing about 28.7% weight loss over 68 weeks (TRIUMPH-4) versus orforglipron at 36 mg producing about 12.4% over 72 weeks (ATTAIN-1)

PT-141 is used as needed

None of those happen on tirzepatide

This makes it a valuable tool in managing chronic conditions linked to obesity

Phase 3 MASLD master protocol (NCT07165028, see Retatrutide and fatty liver): multi-agent MASLD program that includes retatrutide not a dedicated retatrutide-only liver trial