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PT-141 is a derivative of Melanotan II (a tanning peptide)

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2023 [cited 2026 Feb 11];14:28394

GLP-1 Binding The EM structure of the GLP-1 apo receptor (i.e., receptor in the absence of any ligand), shows that the N-terminal domain adopts a closed or inactive conformation, where a cap-like structure blocks access to the peptide binding ( PDB ID 6ln2, Wu et al., 2020, Figure 4a)

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