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First, neurotransmitter metabolism becomes dysregulated, particularly in the serotonin and GABA systems

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[DOI] [PubMed] [Google Scholar] 108.Vaughan R.A., Mermier C.M., Bisoffi M., Trujillo K.A., Conn C.A

Chronic high blood sugar levels initiate a cascade of metabolic abnormalities, which ultimately induce oxidative stress and inflammation, exacerbating nerve injury through excessive production of reactive oxygen species (ROS) and promoting neuronal apoptosis

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