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Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin

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This leads to upregulation of pro-inflammatory cytokines and microglial activation in the hippocampus, ultimately suppressing the generation of Bromodeoxyuridine-positive/Doublecortin-positive (BrdU+/DCX+) immature neurons and Bromodeoxyuridine-positive/Neuronal Nuclei-positive (BrdU+/NeuN+) mature neurons

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