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In a recent study published in the JAMA Network Open , a group of researchers evaluated the impact of exercise, glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide, and their combination on bone health at the hip, spine, and forearm following diet-induced weight loss in adults with obesity

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Future research should prioritize the refinement of GLP-1based therapies by addressing limitations such as elevated GLP-1 levels and receptor desensitization, while ensuring their safety and efficacy in older populations

doi: 10.1007/s00011-021-01495-6 60 LiuYGuW

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These temporally distinct phases involve coordinated physiological and molecular processes that sustain ion homeostasis, regulate osmotic balance, and preserve cellular integrity (Van Zelm et al