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Role of mitochondrial dynamics in heart diseases

Yamanashi T, Iwata M, Kamiya N, Tsunetomi K, Kajitani N, Wada N, Iitsuka T, Yamauchi T, Miura A, Pu S, Shirayama Y, Watanabe K, Duman RS, Kaneko K

(2016) found that acute fluoxetine administration in prepubertal female rats resulted in increased estradiol concentrations, whereas subchronic administration led to increased serotonin concentrations in the ovaries, a decrease in the number of ovulations, a greater number of atretic follicles, and oocyte fragmentation

Unwanted proteins are degraded by the 26S proteasome, which consists of a 20S core and a 19S regulatory subunit

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The approval gives Ozempic (semaglutide) the broadest label in the class, coming after earlier approvals for type 2 diabetes itself and cardiovascular risk reduction in diabetics with known heart disease