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33 CONCLUSION While these findings are encouraging, especially for diseases such as psoriasis and HS in which patients often are heavier and may have comorbidities like type 2 diabetes, insulin resistance, or metabolic syndrome, its important to recognize that most data to date come from small observational or retrospective studies with multiple possible confounders
The weight regain patterns observed with other agonists suggest that maintaining lifestyle changes during the treatment period is crucial for sustaining results after discontinuation
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Research efforts are also focused on understanding how variations in experimental conditions, peptide concentration, and molecular stability may affect GLP-3R peptide behavior across different in vitro systems and analytical frameworks