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Several additional hepatoprotective agents have shown promise in reducing methotrexate-induced liver injury, including melatonin (Abdallah et al

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A conserved motif PL 34.51 QXR 34.54 VWT is present in CCKR ICL2s (Figs

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Hardeland R

These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential