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Another study reported significantly elevated agmatine concentrations in both the plasma and postmortem frontal cortex tissue of first-episode and chronic schizophrenia patients (9093), and found that antipsychotic treatment could reduce blood agmatine levels (94)

doi: 10.1016/j.fsi.2022.08.027

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However, topical application with microneedling can significantly enhance absorption, approaching injectable effectiveness for some users