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GLP-1 and Food Cravings: Breaking the Reward-Seeking Cycle Beyond basic hunger suppression, GLP-1 medications reduce the brain's reward response to food, especially high-fat and high-sugar items

3 and 5) blood pressure, by causing vasodilation and inhibiting the sympathetic nervous system

In type 1 diabetes, this mechanism is broken because the pancreas doesnt produce insulin

In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin

HR = 1.41

Tirzepatide is a lab-made peptide that mimics two hormones your gut releases naturally after a meal: GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1)