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[126] demonstrated that STAT3 signaling activated the expression of IDO, a major inducer of the immunosuppressive milieu, without the need for binding of STAT3 protein to the promoter of IDO gene in human MDSCs

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Sodium nitroprusside is disodium pentacyanonitrosylferrate, most often in the dihydrate form: Na 2 [Fe(CN) 5 NO]2H 2 O