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In human experiments, the acute insulin response (AIR) to glucose, AIR to arginine, and, maximal AIR to arginine were significantly correlated with estimates of -cell mass, with r values of ~0.80 [18]

Biomarker findings show dysregulated endocannabinoid levels, with some studies reporting elevations and others reductions

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Although it remains unclear whether the glycogen accumulation reflects increased glucose uptake or reduced oxidation, these findings suggest a shift in hepatic carbohydrate flux toward storage and anabolic processing, potentially reflecting enhanced hepatic insulin sensitivity in the absence of GPR146

The compound that made ghrelins discovery possible remains the right tool when the question extends beyond the pituitary

10.1136/jim-2021-001952