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An example of such can be observed in a study where Cre-dependent activation of Ube3a in Ube3a Stop/p+ embryonic mice restored all AS-associated motor, behavioral, and neurological deficits, whereas Ube3a reactivation in postnatal mice demonstrated diminishing efficacy with age for motor coordination rescue [183]

Functional targeting of cancer-associated fibroblasts (CAFs) using a combination of DFO and follistatin-like protein 1 (FSTL1) -neutralizing antibody significantly alleviated CAF-induced natural killer cell (NK cell) ferroptosis and boosted the cytotoxicity of NK cells against GC [104]

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Mutations in genes such as SNCA, LRRK2, PARK7, PINK1, and VPS35 are associated with familial forms of PD, while pesticide exposure, heavy metals, and industrial chemicals contribute to sporadic cases

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