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By layering on and integrating proteomics data with metabolite and lipid biomarker discoveries, we can deliver multi-dimensional, multi-omics insight into the molecular mechanisms underlying GLP-1 to decipher the heterogeneity of GLP-1 biology and GLP-1 agonist responsiveness more fully

Toxic metabolites, such as hydroxyeicosatetraenoic acid from arachidonic acid metabolism, further exacerbate cardiac hypertrophy and failure ( NLRX1 ubiquitination is induced by LPS, and NLRX1 deficiency exacerbates cardiac injury by enhancing NF-B and NLRP3 inflammasome activation, while diminishing the protective effects of CYP2J2/epoxyeicosatrienoic acid

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Certain proteins and peptides cross intestinal epithelium through transcytosis and other transport mechanisms

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