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Systematic Review (Pivotal and Protocol Selected Studies) Objectives To perform a systematic review of the beneficial and harmful effects of semaglutide 2.4 mg for SC injection as an adjunct to a reduced caloric diet and increased physical activity for chronic weight management in adult patients Methods Studies selected for inclusion in the systematic review included pivotal studies provided in the sponsors submission to CADTH and Health Canada, as well as those meeting the selection criteria presented in Table 5

GLP-1 and cardiovascular health in women Research suggests GLP-1 medications may offer cardiovascular benefits, which is particularly relevant for women after menopause when heart disease risk increases

What clinical evidence supports GLP-1 therapy for weight loss

10.1017/S0007114519002484