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TABLE 3 IL-10 cytokine values measured in the supernatant collected from cells stimulated with LPS following treatment with postbiotics or the related matrices alone

Although the BEACON study showed a significant increase in eGFR by 5.5 mL/min/1.73 m 2 in the group treated with 20 mg/day CDDO-ME, this clinical trial was terminated in 2012 because of the high incidence of cardiovascular events, especially heart failure, in the group treated with CDDO-ME (Table 3) [16]

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Cysteine may be obtained from extracellular cysteine or cystine and, in some tissues, from the methionine cycle through the transsulfuration pathway