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32,33,35 The lack of accumulation of intermediary metabolites suggests that the defect is located in the initial step of methionine transformation regulated by SAM synthe-tase

The key rationale for a universal vaccine approach is the continued burden of disease associated with endemic human coronaviruses (HCoVs), the unpredictability of future SARS-CoV-2 variants, and the potential for zoonotic spill-over events