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260,261 Owing to its rate-limiting enzymatic activity in NAD + salvage pathway, the elevated expression of NAMPT in the innate immune cells, including macrophages and dendritic cells, further proposed a link between intracellular NAD + levels and inflammation

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In older adults, THC can increase the risk of neuropsychiatric symptoms, such as confusion, psychomimetic effects, along with an increased risk of falling, drug-drug interactions via CYP250 enzymes, altered pharmacodynamics, necessitating cautious dosing and monitoring, especially in those with frailty or comorbidities (Hsu et al., 2025

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