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Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

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To differentiate between contributions from endothelial versus hematopoietic cells in Dpp4 EC/ mice, we performed bone marrow transplantation (BMT) using WT donor bone marrow transplanted into Dpp4 EC/ and Dpp4 EC+/+ mice to produce Dpp4 EC/ (BMT) and Dpp4 EC+/+ (BMT) mice, respectively (20)

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