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308 , E414E425 (2015)

Our findings suggest that GLP-1RAs might be just as safe and effective in adults with mental illness as they are in mentally healthy individuals, significantly reducing psychotropic drug-induced weight gain and improving glucose control, while protecting cardiometabolic health

For instance, Recouvreux et al

Darren McGuire, a cardiologist at UT Southwestern in Dallas, Texas, called the FDAs approval a "landmark decision in the field of medical therapy for obesity." He told Fox News Digital, "With this FDA action, semaglutide becomes the first medication ever in the U.S

They plateau on semaglutide and wonder if the "equivalent" tirzepatide dose would work better, without realizing no true equivalence exists

However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.