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MT-II and PT-141 analogs from the Hruby program preceded clinical validation by afamelanotide (Scenesse) and bremelanotide (Vyleesi)

In this study, chronic NTG injection induced an increase in microglial cell numbers and a significant reduction in microglial process length and inflammatory factor (IL-1 and TNF-) release

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Increased hepatocyte growth factor secretion by placenta-derived mesenchymal stem cells improves ovarian function in an ovariectomized rat model via vascular remodeling by Wnt signaling activation

Nat Metab 5(2):186192

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