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GLP-1 drugs mimic the effects of this hormone

Patients feeling nauseated or fatigued may decrease their usual exercise routines, leading to deconditioning

2012;303(7):E899-907

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Stress management through practices like meditation, yoga, or regular relaxation techniques helps optimize cortisol levels

For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. For now, the mechanism driving GLP-1 resistance remains unresolved, but it is likely complex and multifactorial, Gloyn said