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doi: 10.1016/j.copsyc.2015.09.005 32 FardoulyJDiedrichsPCVartanianLRHalliwellE

Nausea and gastrointestinal adjustment typically occur during dose escalation and resolve within 25 days

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Metformin, by contrast, has been the subject of debate regarding whether it may partially blunt exercise-induced mitochondrial adaptations in some populations, though this remains contested in the literature

This gradual approach allows your gastrointestinal system to adapt and reduces severe nausea or other side effects

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