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DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes

Diabetes 2002;51 Suppl 3(S434442

He noticed that it pushed older liver tissue to make proteins more like those in younger tissue

In those patients, addressing the underlying metabolic dysfunction first, through dietary intervention, GLP-1 therapy if indicated, or NAD+ support for cellular energy metabolism, is the clinical priority

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