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62 Therefore, the existence of the cephalic phase of insulin secretion remains controversial and it appears to have minimal, if any, physiological relevance

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It is the job of the L cells to secrete GLP-1s and PYY to stimulate insulin secretion from the pancreatic beta cells, inhibit glucagon release, and slow gastric emptying after a meal

Because of these differences, Contrave may be combined with other treatments in select cases when medically appropriate, especially for patients who need both physiologic appetite reduction and behavioral craving support

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