DPP-IV cleaves GLP-1 at the peptide bond between Ala8-Glu9 (Fig
In the STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) for obesity, participants with baseline binge eating behaviors showed improvements in eating-related measures alongside weight loss, as assessed by questionnaires such as the Control of Eating Questionnaire
Instead of one larger weekly dose that spikes and fades, EOD spreads the signaling across the week
Unregulated online sources should always be avoided due to safety and dosing concerns
Our view: Oral GLP-1 supplementation, combined with good nutrition and consistent habits, is the more evidence-supported non-prescription option
Green tea, gymnema, turmeric, and B vitamins provide antioxidant and metabolic support