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This reduction hampers their ability to produce energy and maintain a healthy redox balance

Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL Receptor-2 expression

At this concentration, reaching the standard starting dose of 0.25 mg requires drawing 25 units

Scientific data shows that they may also reduce the likelihood of cardiovascular events of stroke and improve cardiovascular outcomes

Pausing weekly injections for glycemic control at least 1 week Longer interruption when prescribed solely for obesity, when feasible Encouraging a clear-fluid diet for approximately 24 hours pre-procedure Using gastric ultrasound whenever possible The most important tool: Gastric ultrasound has emerged as the most recommended bedside technique to assess aspiration riskbecause fasted is not always empty. How it helps you make real decisions: Empty / low risk proceed with planned anesthetic (with judgment) Clear fluid with high volume or solids treat as higher aspiration risk, delay if elective or choose an airway-protective technique Urgent or emergency procedures: If the case is urgent, fasting history or symptoms are concerning, or ultrasound is unavailable or inconclusive: Treat as potentially full stomach Consider rapid sequence induction and cuffed endotracheal intubation rather than deep sedation without a protected airway References ASA consensus-based guidance on preoperative management of patients on GLP-1 receptor agonists 2025 narrative review on GLP-1 receptor agonists and anesthesia Delayed gastric emptying with GLP-1s is not an issue for OFA that eliminates PONV even in Apfel-defined high PONV risk patients WITHOUT antiemetics

We are finalizing that these policies are effective as of January 1, 2026, but we will delay enforcement of the requirements until April 1, 2026