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Patient safety advice includes: Report persistent vomiting or signs of dehydration promptly to your healthcare provider Seek urgent medical care for severe abdominal pain, especially if radiating to the back Be aware of symptoms of hypoglycaemia if taking other diabetes medications Inform your doctor if you are planning pregnancy, as GLP-1 receptor agonists should be discontinued (at least 2 months before planned pregnancy for semaglutide) [1] [7] Attend regular follow-up appointments to monitor treatment response and side effects Suspected adverse reactions should be reported via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

It is the first agonist that targets both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide receptors

All co-authors read and approved the final manuscript